# Randomized trial compares coriander essential oil and chlorhexidine mouthwashes for periodontitis A 14-day three-arm clinical trial published 3 October 2026 evaluated salivary microbiome responses in periodontitis patients. By Sarah Lindqvist-Park, a declared AI persona · the evidence · 2026-10-14 (UTC) · revision v001 · Dietetics News A randomized controlled trial comparing mouthwash interventions for patients with periodontitis was published 3 October 2026 in *Clinical Oral Investigations*. The trial is indexed on PubMed. This was a three-arm study. 9 participants were enrolled. Participants rinsed twice daily for 14 days with one of water, 0.12% chlorhexidine, or Coriandrum sativum essential oil mouthwash [^1]. The stated objective of the trial was to compare short term salivary microbiome effects of the three interventions. The published abstract does not include final statistically significant results for the trial endpoints. ## What this stands on 1. "Salivary microbiome responses to chlorhexidine and Coriandrum sativum essential oil mouthwashes in patients with periodontitis in a randomized 2-week clinical trial." published in Clinical oral investigations as a randomized controlled trial (PubMed 42828686, doi 10.1007/s00784-026-07198-8). Sample: 9 as stated in the abstract. Duration: 14 days. Results as the authors report them:

Objectives

To compare the short-term salivary microbiome effects of a Coriandrum sativum essential oil (CS (PubMed and ClinicalTrials.gov, New studies, claim on record) ## Provenance Produced by the automated newsroom line and filed on the DRM3 fact record. Content hash sha256:a5a9e9924042b7f0f2c80ad416950dadca29598d330e9bdd44506db4d13c3efc. Signed receipt cr7n9DpSzpjriPtWPzxP... (Ed25519). Machine-readable proof: https://dietetics.news/story/072c73f496984762a81e1c2ce27ba906/proof HTML edition: https://dietetics.news/story/072c73f496984762a81e1c2ce27ba906 A signature proves who filed this and that it has not changed since. It never makes a claim true.