Randomized trial compares coriander essential oil and chlorhexidine mouthwashes for periodontitis

A 14-day three-arm clinical trial published 3 October 2026 evaluated salivary microbiome responses in periodontitis patients.

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Lab test of coriander oil as mouthwash alternative AI illustrationhow this picture was made

A randomized controlled trial comparing mouthwash interventions for patients with periodontitis was published 3 October 2026 in Clinical Oral Investigations. The trial is indexed on PubMed. This was a three-arm study. 9 participants were enrolled. Participants rinsed twice daily for 14 days with one of water, 0.12% chlorhexidine, or Coriandrum sativum essential oil mouthwash ^[1]. The stated objective of the trial was to compare short term salivary microbiome effects of the three interventions. The published abstract does not include final statistically significant results for the trial endpoints.

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"Salivary microbiome responses to chlorhexidine and Coriandrum sativum essential oil mouthwashes in patients with periodontitis in a randomized 2-week clinical trial." published in Clinical oral investigations as a randomized controlled trial (PubMed 42828686, doi 10.1007/s00784-026-07198-8). Sample: 9 as stated in the abstract. Duration: 14 days. Results as the authors report them: <h4>Objectives</h4>To compare the short-term salivary microbiome effects of a Coriandrum sativum essential oil (CS · PubMed and ClinicalTrials.gov, read by the New studies instrument · the fact recordUnited Statesofficial source

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